Detecting negative selection on recurrent mutations using gene genealogy
نویسندگان
چکیده
منابع مشابه
Analysis of Missense Mutations of CX3CR1 Gene in Patients with Recurrent Pregnancy Loss Using Bioinformatics Tools
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In genetics, the Ka/Ks ratio is the ratio of the number of non-synonymous substitutions per non-synonymous site (Ka) to the number of synonymous substitutions per synonymous site (Ks)[1]. Ka/Ks ratio was used as an indicator of selective pressure acting on a protein-coding gene. A Ka/Ks ratio of 1 indicates neutral selection, i.e., the observed ratio of non-synonymous mutations versus synonymou...
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Detecting positive selection is a challenging task. We propose a method for detecting past positive selection through ongoing negative selection, based on comparison of the parameters of intraspecies polymorphism at functionally important and selectively neutral sites where a nucleotide substitution of the same kind occurred recently. Reduced occurrence of recently replaced ancestral alleles at...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2013
ISSN: 1471-2156
DOI: 10.1186/1471-2156-14-37